Abstract The objective of this study was to evaluate the effects of the addition of different concentrations of ozone to quarter horse semen submitted to cryopreservation. Six ejaculates from four stallions were collected and were divided in four experimental groups: a control group (BotuCRIO® extender) and three other groups with BotuCRIO® ozonized at concentrations of 6, 8 and 12 μg of O3/mL. The semen samples were diluted (200 x 106 spermatozoa/mL), filled in straws and frozen. After thawing (37 ºC, 30s), the samples were evaluated at 0, 30 and 60 minutes of incubation regarding sperm kinetics by a computer-assisted sperm analysis (CASA), and plasma membrane integrity (PMI), acrosome integrity (ACi) and mitochondrial membrane potential (MMP) by fluorescent probes. There was a reduction in the kinetic parameters total motility (TM), progressive motility (PM), curvilinear velocity (VCL), straight line velocity (VSL) and average path velocity (VAP) in all groups during the thermoresistance test (TT), a pattern also found in PMI and MMP analyses (p<0.05). There was no difference (p>0.05) between the control and treatment (6, 8, and 12 μg of O3/mL) groups, in any of the evaluated times for the kinetic parameters TM, linearity (LIN), straightness (STR), wobble index (WOB), amplitude of lateral head displacement (ALH) and beat cross frequency (BCF). Regarding the VCL, VSL and VAP parameters, the group treated with 6 μg did not differ from the control or from 8 μg, but was higher than 12 μg at 30 and 60 minutes. ACi and PMI did not differ between groups (p>0.05), but PMI was lower in groups 8 μg and 12 μg compared to the control and 6 μg (p<0.05). It was concluded that the addition of ozone does not present beneficial effects for cryopreservation of equine semen at the concentrations used and decreases important parameters of fertility.

A pitiríase rotunda é dermatose rara, caracterizada por placas circulares bem definidas, hipo ou hiperpigmentadas, localizadas no tronco e porção proximal dos membros. São descritos dois subtipos: o tipo I acomete pacientes negros e orientais sem história familiar de pitiríase rotunda e está relacionado com doença sistêmica concomitante; o tipo II ocorre em caucasianos com história familiar e sem doença subjacente. Descreve-se um caso do tipo I em mulher negra de 39 anos.

Pityriasis rotunda is a rare dermatosis characterized by sharply defined, hypo- or hyperpigmented circular plaques, located in the trunk and proximal extremities. There are two described subtypes: type I affects Black or Eastern patients without family history of pityriasis rotunda and is associated with simultaneous systemic illness; type II occurs in Caucasians with a family history of pityriasis rotunda and without underlying disease. In this article we report the case of type I pityriasis rotunda in a 39-year-old black woman.

A psoríase é doença crônica que acomete entre 0,1 e 3% da população mundial e cujo impacto social e psicológico costuma ser subestimado.¹ Muitos estudos têm relatado o impacto produzido por essa doença na qualidade de vida dos pacientes, e questionários para analisar objetivamente essa incapacidade estão sendo descritos.1,2 É importante avaliar a percepção do portador de psoríase em relação a seu estado de saúde, incapacidade e qualidade de vida a fim de estabelecer a melhor terapêutica para cada indivíduo. Este artigo de EMC-D aborda a validação de dois questionários de avaliação da qualidade de vida para a língua portuguesa.

Psoriasis is a chronic disease that affects about 0.1 to 3% of the world's population and most people underestimate the social and psychological impact of the disease.¹ MSeveral studies have described the many ways in which psoriasis affects patients' lives, and techniques have been described to quantify the disability caused.1,2 It is important to assess the perceived levels of health status, disability and quality of life when considering what kind of treatment options to offer patients with psoriasis. Underscoring the importance of this, the EMC-D article focuses on a validation of two quality of life questionnaires translated into Brazilian Portuguese.

Embora a fisiopatologia da psoríase ainda não esteja totalmente esclarecida e permaneçam dúvidas quanto à natureza dos antígenos que levam à ativação do linfócito T e quanto ao papel dos mecanismos reguladores dos surtos e da resolução da inflamação, são inegáveis os avanços terapêuticos das últimas décadas. Além do surgimento de novos medicamentos, a melhor utilização de tratamentos clássicos e a valorização do impacto da terapêutica na qualidade de vida dos pacientes têm contribuído para a diminuição dos índices de morbidade da doença. Este artigo de EMC-D aborda a utilização de metotrexato e acitretina no tratamento da psoríase. A utilização de outros imunomoduladores e de terapias biológicas será objeto de próximo capítulo.

The physiopathology of psoriasis has not yet been thoroughly clarified. Although there has been undeniable progress in the last decade, doubts remain about the nature of the antigens, which lead to activation of T lymphocytes, and about the regulation of the inflammatory mechanisms. Besides the development of new therapies, the improved management of classical systemic treatments has contributed to reduce the morbidity rate of the disease and has achieved a positive impact on the patients' quality of life. Underscoring the importance of this, the EMC-D article focuses on a review of using Methotrexate and Acitretin in the treatment of psoriasis. The use of biological therapies and other immunomodulators will be discussed in a future chapter.